10-Hydroxy camptothecin 99% HPLC

CAS#: 67656-30-8

Main Contents: 10-Hydroxy camptothecin

Plant Resource: Camptotheca acuminata
Main Specification: 99% HPLC

Appearance: Light Yellow Needle-like crystal
Plant Part Used: Fruit
Extract Solution: Ethanol

Molecular Weight: C₂₀H₁₆N₂O₅

Molecular Mass: 364.35

Melting point: 260°C

Solubility: Soluble in Ethanol

What is Camptotheca acuminata?

The Happy Tree, Cancer Tree, or Tree of Life (Camptotheca acuminata) is a genus of medium-sized deciduous trees growing to 20 m tall, native to southern China and Tibet. They are usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. Camptotheca is used to make Irinotecan, Topotecan, 9-Aminocamptothecin, and camptothecin-1 (CPT-1). It also contains trifolin and hyperoside.

What is 10-Hydroxy camptothecin?

10-Hydroxycamptothecin, the derivative of camptothecin, is a minor alkaloid isolated from Camptotheca acuminata (a tree native to mainland China), At present, as an alkaloid anticancer, It is the only known natural DNA Topo isomerase inhibitors. Soluble in methanol, chloroform, acetonitrile; insoluble in water, Its sodium salt is soluble in water, its organic solution has blue fluorescence.

Where will 10-Hydroxy camptothecin be used for?

Pharmacological activity: Anti-cancer activity
Indication: Anti-cancer drug, suitable for treatment of breast and rectum cancers, liver cancer, stomach cancer, malignant melanoma, small-cell lung cancer and leukemia.
Side effects: The major side effects of hydroxycamptothecin are potentially severe diarrhea, nausea, lowered leukocyte (white blood cell) counts and also damage bone marrow, but much less than camptothecin.

Packing Detail:Packed in paper-drums and two plastic-bags inside. Net Weight: 25kgs/drum. I.D. 40CmX50CM
Storage Situation:Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.
Shelf Life:Two years under well Storage situation and stored away from direct sun light.